A new study uses a powerful genetic tool called Mendelian randomization to examine the relationship between meal-related insulin secretion and body mass. The results suggest that gene variants that increase post-meal insulin release may modestly increase body mass. Upon close examination, the findings do not appear to support the hypothesis that insulin is the primary driver of obesity, but they may nevertheless provide a foot in the door for insulin.
Gerald Reaven is the researcher who first identified the state of insulin resistance and played a central role in defining its consequences. Understanding insulin resistance is worthwhile, and if we want to do so, his work is one of the most informative places to look. I recently read his general-audience book Syndrome X: The Silent Killer, and I’ll share my thoughts on it in this review.